U.S. stocks mixed at close of trade; Dow Jones Industrial Average down 0.46%

Investing.com – U.S. stocks were mixed after the close on Wednesday, as gains in the , and sectors led shares higher while losses in the , and sectors led shares lower.

At the close in NYSE, the lost 0.46% to hit a new 3-months low, while the index fell 0.38%, and the index climbed 0.17%.

The best performers of the session on the were Pfizer Inc (NYSE:), which rose 2.33% or 0.79 points to trade at 34.72 at the close. Meanwhile, Apple Inc (NASDAQ:) added 1.59% or 4.57 points to end at 292.65 and 3M Company (NYSE:) was up 1.44% or 2.11 points to 148.96 in late trade.

The worst performers of the session were Walt Disney Company (NYSE:), which fell 3.77% or 4.83 points to trade at 123.36 at the close. Chevron Corp (NYSE:) declined 2.65% or 2.67 points to end at 98.04 and Exxon Mobil Corp (NYSE:) was down 2.20% or 1.19 points to 53.01.

The top performers on the S&P 500 were TJX Companies Inc (NYSE:) which rose 7.15% to 63.99, Gilead Sciences Inc (NASDAQ:) which was up 6.56% to settle at 74.70 and CME Group Inc (NASDAQ:) which gained 5.69% to close at 220.18.

The worst performers were Royal Caribbean Cruises Ltd (NYSE:) which was down 8.05% to 82.34 in late trade, Norwegian Cruise Line Holdings Ltd (NYSE:) which lost 7.89% to settle at 36.21 and TripAdvisor Inc (NASDAQ:) which was down 7.85% to 23.61 at the close.

The top performers on the NASDAQ Composite were Tonix Pharmaceuticals Holding Corp (NASDAQ:) which rose 122.55% to 0.900, Co-Diagnostics Inc (NASDAQ:) which was up 106.26% to settle at 8.900 and Vir Biotechnology Inc (NASDAQ:) which gained 60.95% to close at 34.98.

The worst performers were Aptorum Group Ltd Class A (NASDAQ:) which was down 53.47% to 6.70 in late trade, Microvision Inc (NASDAQ:) which lost 53.05% to settle at 0.2744 and Menlo Therapeutics Inc (NASDAQ:) which was down 32.27% to 2.98 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 1928 to 907 and 68 ended unchanged; on the Nasdaq Stock Exchange, 1715 fell and 956 advanced, while 60 ended unchanged.

Shares in TJX Companies Inc (NYSE:) rose to 3-years highs; up 7.15% or 4.27 to 63.99. Shares in Royal Caribbean Cruises Ltd (NYSE:) fell to 3-years lows; losing 8.05% or 7.21 to 82.34. Shares in Gilead Sciences Inc (NASDAQ:) rose to 52-week highs; up 6.56% or 4.60 to 74.70. Shares in Norwegian Cruise Line Holdings Ltd (NYSE:) fell to 3-years lows; falling 7.89% or 3.10 to 36.21. Shares in TripAdvisor Inc (NASDAQ:) fell to all time lows; falling 7.85% or 2.01 to 23.61. Shares in Chevron Corp (NYSE:) fell to 3-years lows; falling 2.65% or 2.67 to 98.04. Shares in Exxon Mobil Corp (NYSE:) fell to 5-year lows; falling 2.20% or 1.19 to 53.01. Shares in Aptorum Group Ltd Class A (NASDAQ:) fell to all time lows; falling 53.47% or 7.70 to 6.70. Shares in Co-Diagnostics Inc (NASDAQ:) rose to all time highs; up 106.26% or 4.585 to 8.900. Shares in Microvision Inc (NASDAQ:) fell to all time lows; down 53.05% or 0.3100 to 0.2744. Shares in Vir Biotechnology Inc (NASDAQ:) rose to all time highs; rising 60.95% or 13.24 to 34.98. Shares in Menlo Therapeutics Inc (NASDAQ:) fell to all time lows; losing 32.27% or 1.42 to 2.98.

The , which measures the implied volatility of S&P 500 options, was down 1.04% to 27.56.

Gold Futures for April delivery was down 0.43% or 7.15 to $1642.85 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in April fell 2.57% or 1.28 to hit $48.62 a barrel, while the May Brent oil contract rose 0.09% or 0.05 to trade at $52.84 a barrel.

EUR/USD was up 0.05% to 1.0884, while USD/JPY fell 0.05% to 110.36.

The US Dollar Index Futures was up 0.19% at 99.090.

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