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Aspartame, one of the world’s most popular artificial sweeteners, is expected to be labeled a possible carcinogen by the cancer research arm of the World Health Organization (WHO), a move that could shake the food and beverage industry to its core.
“[The International Agency for Research on Cancer (IARC)] has assessed the potential carcinogenic effect of aspartame,” the WHO said in a statement to Fortune. “Following this, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) will update its risk assessment exercise on aspartame, including the reviewing of the acceptable daily intake and dietary exposure assessment for aspartame.”
The results of both evaluations will be released simultaneously on July 14.
Aspartame is used in everything from Diet Coke to sugarless chewing gum to Dannon Activia yogurt. It’s also used in cough drops and some toothpastes. The WHO label indicates there is limited evidence linking aspartame to cancer. It is the lowest of three categories, with “probable carcinogen” (such as the herbicide glyphosate) and “carcinogenic to humans” (i.e. tobacco smoking and asbestos) the next possible steps.
The ruling from the IARC will reportedly not factor how much aspartame a person can safely consume. That advice will be determined by the JECFA.
The WHO last studied aspartame in 1981, determining an acceptable daily intake (40 mg per kilogram—2.2 lbs—of body weight). The new study was undertaken given the availability of new research results.
Word of the pending declaration had put the food industry on the defensive. Coca-Cola did not immediately respond to Fortune’s request for comment, but the International Sweeteners Association, which represents manufacturers of low- and no-calorie sweeteners, including aspartame, said it had “serious concerns” about the opinion.
“IARC is not a food safety body,” said Frances Hunt-Wood, Secretary General of the International Sweeteners Association in a statement. “No conclusions can be drawn until both reports are published. Aspartame is one of the most thoroughly researched ingredients in history, with over 90 food safety agencies across the globe declaring it is safe.”
The International Council of Beverages Associations, a trade organization for the non-alcoholic beverage industry, also condemned the leaking of the report, saying it “could needlessly mislead consumers into consuming more sugar rather than choosing safe no- and low-sugar options.”
The classification is the latest blow to sugar substitutes by the WHO. Last month, the group advised consumers to stop using non-sugar sweeteners for weight control, saying they did not help with weight loss. (That guidance, however, did not point to any possible health risks.)
