Need to Know: Stock picking in 2022? Goldman Sachs says these are the companies that should be on your radar.

So here’s some investing advice for the new year straight off the bat from Goldman Sachs. “For 2022, investors should focus on stocks with high growth and high margins and avoid firms with high exposure to wage inflation,” said a team led by top U.S. equity strategist David Kostin.

He points out that most active managers missed out on that “terrific” 2021 for equities. And while some may point to below-historical-average volatility and market breadth as reasons for those managers not finding diamonds last year, he argued there were still opportunities to be found.

“The dispersion of return measured as +/- one standard deviation around the average stock equaled 59 percentage points (0% to +59%), modestly below the long-term average, but still robust. Unfortunately, active fund managers were unable to capture the available alpha,” he said.

Read: These were the best-performing S&P 500 and Nasdaq-100 stocks of 2021

As Goldman Sachs explained, some environments work out better for stock pickers. “A micro-driven market means the share of the median stock’s return that is explained by company-specific factors is high. By contrast, in a macro-driven market the return structure for the typical stock is primarily explained by factors such as beta, sector, size, and valuation,” said the team.

For example, during the spring 2020 COVID-19 wave, the macro contribution to stock returns peaked at nearly 80%, leaving just 20% to company-specific reasons. Since then, returns have been driven less by macro factors, said Kostin. “Core mutual funds are slightly more likely to outperform during market environments that are more micro-driven than average,” he added.

And for 2022, variables linked to earnings and valuations should determine how S&P 500 companies fare, the strategist said. Goldman Sachs predicts the index will finish the year at 5,100, which is at the upper end of Wall Street’s forecasts.

“From an earnings perspective, decelerating economic growth will limit sales gains
for many companies. Consequently, stock return dispersion will be most evident
when viewed through the margin channel. We forecast margin expansion of 40 bp to 12.6% in 2022 which explains our slightly above-consensus EPS [earnings per share] forecast. But rising input costs and labor inflation will pressure margins for some firms. Stocks with high labor cost ratios and exposure to wage inflation will likely underperform,” he said.

Goldman Sachs offered up a few stock possibilities, including these companies on the Russell 3000
RUA,
-0.28%
that have expected high-revenue growth and margins: MP Materials
MP,
+0.35%,
Mastercard
MA,
-0.46%,
United Therapeutics,
UTHR,
+0.42%,
Aspen Technology
AZPN,
+0.13%,
Nvidia
NVDA,
-0.59%
and Marvell Technology
MRVL,
+0.06%.

Companies in its low-labor cost basket include Dish Network
DISH,
-1.25%,
Netflix
NFLX,
-1.58%,
Under Armour
UAA,
+0.71%,
CarMax
KMX,
+1.59%,
Coca-Cola
KO,
+0.73%,
AmerisourceBergen
ABC,
-0.66%,
Apple
AAPL,
-0.35%,
HP
HPE,
-0.76%
and PayPal
PYPL,
-1.72%.

The buzz

Tesla
TSLA,
-1.27%
delivered more than 308,000 autos in the fourth quarter, and reported an 87% jump in deliveries for the year. The stock is up 7% in premarket trading.

Shares of Immix Biopharma
IMMX,
+9.20%
are surging in premarket after the biopharmaceutical group said its pediatric cancer treatment was granted Rare Pediatric Disease (RPD) designation by the Food and Drug Administration.

Weather and COVID-induced staff shortages grounded 2,600 U.S. flights and more than 4,000 globally on Sunday. United
UAL,
-0.79%
is offering pilots triple pay to pick up flights in January. Heavy snowfall is expected to shut down Washington, D.C. on Monday as well.

Goldman Sachs
GS,
-0.77%
is asking employees to work from home until mid January due to a surge of COVID-19 cases caused by the omicron coronavirus variant. JPMorgan
JPM,
-0.08%,
 Bank of America
BAC,
-0.09%
and Citigroup
C,
-0.07%
have also asked employees who can to do the same.

White House chief medical adviser Dr. Anthony Fauci said the Centers for Disease Control and Prevention may consider adding a negative test to its guidance for leaving COVID isolation.

Investors will get some data this week, which ends with December payrolls data.

The markets

Stock futures
ES00,
+0.51%

YM00,
+0.42%

NQ00,
+0.60%
are pointing to a bullish start, after a mixed session from Asia, where several markets remained closed and some gains from Europe
SXXP,
+0.60%.
Oil prices
CL00,
-0.73%

NQ00,
+0.60%
are climbing ahead of Tuesday’s meeting of the Organization of the Petroleum Exporting Countries. The dollar
DXY,
-0.07%
is softer and gold
GC00,
-1.14%
is easing, but still near levels not seen since November.

Top tickers

Here are the top tickers on MarketWatch, as of 6 a.m. Eastern.

Random reads

Twitter
TWTR,
-2.79%
has banned far-right Rep. Marjorie Taylor Greene over COVID misinformation.

Reviews are mixed for actor Matt Damon’s new cryptocurrency ad.

A meteor may have exploded over Pittsburgh.

One-year old gets thumbs-up from the U.K.’s Queen Elizabeth II over copycat look.

Need to Know starts early and is updated until the opening bell, but sign up here to get it delivered once to your email box. The emailed version will be sent out at about 7:30 a.m. Eastern.

Want more for the day ahead? Sign up for The Barron’s Daily, a morning briefing for investors, including exclusive commentary from Barron’s and MarketWatch writers.