Europe Markets: European stocks struggle and Nasdaq futures are higher with investors focused on Fed and big tech earnings

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European stocks struggled for traction on Wednesday, with investors focused on company results and a Federal Reserve meeting for later. Nasdaq-100 futures were climbing after Microsoft results.

The Stoxx Europe 600 index SXXP, -0.08% rose 0.1% to 408.17, after a 0.6% gain on Tuesday. Regional bourses were mixed, with the German DAX DAX, -0.35% down 0.2%, the French CAC 40 PX1, +0.03% up 0.3%, and the FTSE 100 index UKX, -0.11% flat.

After a slightly weaker close for Wall Street on Tuesday, Nasdaq-100 futures NQ00, +0.50% traded higher after technology giant Microsoft MSFT, +1.22% reported record earnings, hitting $40 billion in quarterly sales for the first time. Investors will get results from tech giants Apple AAPL, +0.17% and Facebook FB, +1.45%, along with electric-car maker Tesla TSLA, +0.26% after the close of trading on Wednesday.

Investors will also get a decision from the Federal Reserve, followed by a news conference with Chair Jerome Powell, with hopes the central bank will continue with a supportive stance for markets amid the COVID-19 pandemic.

Global coronavirus virus infections topped the 100 million mark on Tuesday, according to a tally from Johns Hopkins University

The U.K. also reached a milestone on Tuesday, surpassing 100,000 COVID-19 deaths, the first European country to do so. Home Secretary Priti Patel is expected to announce new rules on Wednesday to limit the influx of visitors to the U.K.

Shares of Royal KPN KPN, +4.53% jumped 4%, after the Dutch telecommunications company said fourth-quarter net profit more than doubled, boosted by one-off items. It also raised its cash-flow guidance for 2021.

Shares of Sanofi SNY, -0.97% SAN, +1.06% gained 0.7%, after the pharmaceutical group said it would help BioNTech BNTX, -3.91% produce the COVID-19 vaccine it is codeveloping with U.S. drug company Pfizer PFE, +0.08%.

Sanofi said that it will continue to develop its two candidates against COVID-19. Sanofi and U.K. pharmaceutical group GlaxoSmithKline GSK, +0.82% GSK, +0.10% announced in December a delay of their joint COVID-19 vaccine after the first trials showed an insufficient response in older patients.

Read: Tensions rise in Europe on AstraZeneca COVID-19 vaccine woes

EDF EDF, -3.07% shares fell 2%, after the French utility released an updated schedule and cost estimates for the Hinkley Point C nuclear power station, saying it sees a delay and higher costs due to the pandemic.

Shares of technology firm ASML ASML, -3.28% ASML, -1.98% were down 1.6%.

Another big decliner was Danish shipping giant A.P. Moller-Maersk MAERSK.A, -7.53%, whose shares fell 6%.